Find patient medical information for belantamab mafodotin-blmf intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Blenrep FDA Approval History. FDA Approved: Yes (First approved August 5, 2020) Brand name: Blenrep. Generic name: belantamab mafodotin-blmf. Dosage form: Injection. Company: GlaxoSmithKline. Treatment for: Multiple Myeloma. Blenrep (belantamab mafodotin-blmf) is a B-cell maturation antigen (BCMA)-directed antibody and microtubule inhibitor

More than 49,000 drugs can be searched. 2020-07-09 · Belantamab mafodotin (GSK2857916) is an antibody-drug conjugate (ADC) containing humanized anti- B-cell maturation antigen (BCMA) monoclonal antibody (mAb). Renal impairment is a major complication of multiple myeloma (MM) and majority of MM participants are either at risk or already have renal dysfunction at initial diagnosis. Medscape - Multiple myeloma dosing for Blenrep (belantamab mafodotin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. 2020-07-29 · A Phase 1b clinical trial evaluating GlaxoSmithKline (GSK)’s belantamab mafodotin, in combination with SpringWorks Therapeutics’ nirogacestat, in people with relapsed or refractory multiple myeloma, has dosed its first patient, SpringWorks announced. The safety and preliminary effectiveness of On July 24, 2020, the European Medicines Agency (EMA)’s Committee for Medicinal Products for Human Use recommended granting a conditional marketing authorization in the European Union for belantamab mafodotin, a first-in-class, anti-BCMA immunoconjugate, for the treatment of patients with relapsed and refractory multiple myeloma (RRMM) who are no longer responsive to immunomodulatory agents Early data from the DREAMM-6 study suggest that the combination of belantamab mafodotin, bortezomib, and dexamethasone is active in patients with relapsed or refractory multiple myeloma (MM). 1 These findings were presented by Ajay Nooka, MD, of the Winship Cancer Institute at Emory University in Atlanta, Georgia, as part of the ASCO20 Virtual Scientific Program.

Dosage form: Injection. Company: GlaxoSmithKline. Treatment for: Multiple Myeloma. Blenrep (belantamab mafodotin-blmf) is a B-cell maturation antigen (BCMA)-directed antibody and microtubule inhibitor GlaxoSmithKline plc (LSE/NYSE: GSK) announced the US Food and Drug Administration (FDA) has approved BLENREP (belantamab mafodotin-blmf) as a monotherapy treatment for adult patients with relapsed or refractory multiple myeloma who have received at least four prior therapies including an anti-CD38 monoclonal antibody, a proteasome inhibitor and an immunomodulatory agent. Package insert. GlaxoSmithKline; 2020. Lonial S, Lee HC, Badros A, et al.

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The FDA granted Priority Review to the Biologics License Application for belantamab mafodotin, an anti–B cell maturation antigen monoclonal antibody for the treatment of patients with relapsed or refractory multiple myeloma whose prior therapies included an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 antibody, GlaxoSmithKline plc announced in a press release.

Belantamab mafodotin is an investigational humanised, anti-BCMA (antibody-drug conjugate against B-cell maturation antigen). [1] BCMA is a cell-surface protein that plays an important role in the survival of plasma cells and is universally expressed in patients with multiple myeloma. [2] Find patient medical information for belantamab mafodotin-blmf intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Belantamab Mafodotin (Belamaf) Clinical Safety Results Hesham A. Abdullah, MD, MSc, RAC Senior Vice President Head of Clinical Development Oncology GlaxoSmithKline PLC. CO-33 Belamaf 3.4 mg/kg

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( [WEB] ) or by phone (1-800-332-1088). These results were observed in patients receiving the recommended dose of 2.5 mg/kg. The prescribing information includes a Boxed Warning stating belantamab Apr 5, 2021 Generic Name: belantamab mafodotin-blmf A package insert is required by the FDA and contains a summary of the essential scientific Jan 1, 2021 frequently than listed in the package insert, or generally accepted by peers 1.0 Belantamab mafodotin-blmf requires prior authorization and is Aug 7, 2020 The FDA has granted accelerated approval to Blenrep (belantamab mafodotin- blmf; GlaxoSmithKline) for the Blenrep [package insert]. Jan 1, 2021 BLENREP® (belantamab mafodotin-blmf) Prior Auth Criteria Absence of unacceptable toxicity from the drug.

Belantamab mafodotin-blmf may cause other side effects.
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Pom will be administered orally at 4 mg on Days 1-21 of each 28-day cycle, with Dex 40 or 20 mg (depending on age) on Days 1, 8, 15, and 22. Belantamab mafodotin-blmf (Blenrep) has elicited significant responses in patients with relapsed/refractory multiple myeloma, but the corneal toxicities associated with its use will require a 2021-03-17 · Belantamab mafodotin-blmf injection is used to treat multiple myeloma (a type of cancer of the bone marrow) that has returned or has not improved in adults who have received at least 4 other medications. Belantamab mafodotin-blmf is in a class of medications called antibody-drug conjugates. It works by killing cancer cells.

Dosage the package insert, the approval of panobinostat ( Farydak) was based upon the efficacy and safety in a panobinostat • belantamab. Nov 1, 2020 Using the final SV catalog, long-insert low-coverage WGS revealed a signature fitting using the previously described R package mmsig (51, 52). Belantamab mafodotin for relapsed or refractory multiple myeloma . Insert Talk Title Here.
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1. Blenrep [package insert]. Brentford, Middlesex, UK; GlaxoSmithKline, Ltd; August 2020. Accessed January 2021. 2. Referenced with permission from the NCCN Drugs & Biologics Compend ium (NCCN Compendium®) for belantamab mafodotin. National Comprehensive Cancer Network, 2021. The NCCN Compendium® is a derivative work of the NCCN Guidelines

Belantamab mafodotin for relapsed or refractory multiple myeloma ( Belantamab mafodotin is an investigational anti-B-cell maturation antigen (BCMA ) antibody-drug conjugate in Phase II clinical development for patients with Most recently, however, we did have the first BCMA targeted drug, belantamab mafodotin or belamaf, which is an antibody-drug conjugate. Similar to other Dec 4, 2020 Blenrep (belantamab mafodotin-blmf) is an antibody-drug conjugate (ADC).

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BLENREP is a prescription medicine used to treat adults with multiple myeloma who have received at least 4 prior medicines to treat multiple myeloma, and their cancer has come back or did not respond to prior treatment. It is not known if BLENREP is safe and effective in children.

2,5 Belantamab mafodotin specifically binds to BCMA and eliminates myeloma cells by a multimodal mechanism.